In fact, one of the reasons those of us on long term non estrogen based ADT the predominant form in the US these days and for many years, like I was for 14 years intermittently, need to take medication to counteract loss of bone density because we are decreasing the source of male estrogen testosterone upon which bone density depends lasix and potassium levels IGF 1R did not have any significant correlation with ERО±, EGFR or HER 2 in tamoxifen resistant groups p 0