In another aspect, the poorly soluble active pharmaceutical ingredient comprises acetaminophen, acetazolamide, acyclovir, allopurinol, amoxicillin, cefdinir, cefixime, cefotiam hexetil hydrochloride, cefpodoxime proxetil, cefuroxime axetil, dapsone, dexamethasone, doxycycline, famotidine, fexofenadine, folic acid, furosemide, glipizide, griseofulvin, hydrochlorothiazide, 1 carbocysteine, levodopa, levosulpiride, linezolid, meloxicam, mesalamine, metoclopramide, modafinil, nabumetone, nalidixic acid, oxcarbazepine, oxycodone, phenobarbital, propylthiouracil, sulfadiazine, sulfamethoxazole, sultamicillin, theophylline, tosufloxacin, triflusal, trimethoprim, and zaltoprofen or pharmaceutically acceptable salts, isomers, prodrugs e ciproflaxin 2001; 285 24 3107 15