Results The downregulation of MLF1IP could significantly increase the drug sensitivity of Michigan Cancer Foundation 7 MCF 7 cells and also inhibit the proliferation of MCF 7 cells under the stimulation of drugs tamoxifen gynecomastia Both Doxycycline and Azithromycin effectively inhibit the anchorage independent propagation of CSCs, as assessed using the 3D tumor sphere assay, in 12 cell lines derived from 8 different cancer types, including breast cancers MCF7, T47D, MDA MB 231 and MCF10