Consistently, we demonstrate that IL 1?? is the downstream molecule after ReaChR activation for following reasons 1 ReaChR activation induces IL 1?? upregulation in microglia; 2 Inhibition of IL 1?? by IL 1ra ameliorates microglial ReaChR dependent synaptic potentiation in the spinal cord; 3 IL 1ra also inhibits light induced neuronal activation and chronic pain buy cheap generic cialis online