The primary end point of the trial was progression free survival PFS, and key secondary end points comprised OS, health related quality of life, overall response rate ORR, time to definitive deterioration of the ECOG performance status, PFS2, and safety, among others best price cialis CEAs in which the outcome is measured in terms of QALYs produce an Incremental Cost Utility Ratio ICUR, which incorporates quality of life impact into the estimate of value for money