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or a pharmaceutically acceptable salt thereof, wherein X1 is a bivalent moiety selected from a covalent bond, CH2, C O, C S, or R1 is hydrogen, deuterium, halogen, CN, OR, SR, S O R, S O 2R, NR2, or an optionally substituted C1 4 aliphatic; each R2 is independently hydrogen, R6, halogen, CN, NO2, OR, SR, NR2, S O 2R, S O 2NR2, S O R, C O R, C O OR, C O NR2, C O N R OR, OC O R, OC O NR2, N R C O OR, N R C O R, N R C O NR2, or N R S O 2R; Ring A is a bi or tricyclic ring selected from Ring B is a fused ring selected from 6 membered aryl containing 0 2 nitrogen atoms, 5 to 7 membered partially saturated carbocyclyl, 5 to 7 membered partially saturated heterocyclyl with 1 2 heteroatoms independently selected from nitrogen, oxygen or sulfur, or 5 membered heteroaryl with 1 3 heteroatoms independently selected from nitrogen, oxygen or sulfur; R3 is selected from hydrogen, halogen, OR, N R 2, or SR; each R4 is independently hydrogen, R6, halogen, CN, NO2, OR, SR, NR2, S O 2R, S O 2NR2, S O R, C O R, C O OR, C O NR2, C O N R OR, OC O R, OC O NR2, N R C O OR, N R C O R, N R C O NR2, or N R S O 2R; R5 is hydrogen, C1 4 aliphatic, or CN; each R6 is independently an optionally substituted group selected from C1 6 aliphatic, phenyl, a 4 7 membered saturated or partially unsaturated heterocyclic ring having 1 2 heteroatoms independently selected from nitrogen, oxygen, and sulfur, and a 5 6 membered heteroaryl ring having 1 4 heteroatoms independently selected from nitrogen, oxygen, and sulfur; m is 0, 1, 2, 3 or 4; and each R is independently hydrogen, or an optionally substituted group selected from C1 6 aliphatic, phenyl, a 4 7 membered saturated or partially unsaturated heterocyclic having 1 2 heteroatoms independently selected from nitrogen, oxygen, and sulfur, and a 5 6 membered heteroaryl ring having 1 4 heteroatoms independently selected from nitrogen, oxygen, and sulfur, or two R groups on the same nitrogen are taken together with their intervening atoms to form a 4 7 membered saturated, partially unsaturated, or heteroaryl ring having 0 3 heteroatoms, in addition to the nitrogen, independently selected from nitrogen, oxygen, and sulfur propecia price in south africa They found that adding 100 ??g cinnamon per disk produced an inhibition zone of approximately 80 mm wide, which was greater than the inhibition zones produced by several antibiotics 10 ??g ampicillin, 30 ??g tetracycline, 15 ??g erythromycin, 30 ??g nalidixic acid, and 25 ??g co trimoxazole

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